Drug

Who makes buprenorphine hydrochloride and naloxone hydrochloride?

3 companies list buprenorphine hydrochloride and naloxone hydrochloride as a human prescription drug, including under the names Zubsolv. Forms: tablet; tablet, orally disintegrating. Routes: sublingual.

Labellers from the openFDA NDC Directory. A labeller is the firm named on the label, not necessarily the site that made the product, and a listing is not an FDA approval. Data as of 24 Sept 2026. Methodology

Companies listing buprenorphine hydrochloride and naloxone hydrochloride

CompanyFormsApplicationNDCsRegistered sites
Edenbridge Pharmaceuticals LLC.tablet, orally disintegratingNDANDA20424260
Orexo US, Inc.tablet, orally disintegratingNDANDA20424260
PAI Holdings, LLCUnited StatestabletANDAANDA20443121
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Common questions

Who makes buprenorphine hydrochloride and naloxone hydrochloride?
3 companies list buprenorphine hydrochloride and naloxone hydrochloride as a human prescription drug in the openFDA NDC Directory, led by Edenbridge Pharmaceuticals LLC., Orexo US, Inc., PAI Holdings, LLC. Each is the labeller, the firm named on the label; the product may be made at a site registered to another company.
Is there a generic Zubsolv?
1 company lists buprenorphine hydrochloride and naloxone hydrochloride under an abbreviated new drug application (ANDA), the application type used for generics, and 2 under an NDA or BLA. Listing status is from the NDC Directory; it is not a statement of availability.