3 companies list rifaximin as a human prescription drug in the openFDA NDC Directory, led by Salix Pharmaceuticals, Inc., Cardinal Health 418, Inc., International Medication Systems, Ltd.. Each is the labeller, the firm named on the label; the product may be made at a site registered to another company.

Who supplies rifaximin active ingredient?

15 companies list rifaximin as a bulk ingredient, including Olon USA LLC, Granules Pharmaceuticals Inc., MSN Laboratories Private Limited,, ALFASIGMA SPA.

Drug

Who makes rifaximin?

3 companies list rifaximin as a human prescription drug, including under the names XIFAXAN. Forms: tablet. Routes: oral.

Labellers from the openFDA NDC Directory. A labeller is the firm named on the label, not necessarily the site that made the product, and a listing is not an FDA approval. Data as of 24 Sept 2026. Methodology

Companies listing rifaximin

Company	Forms	Application	NDCs	Registered sites
Salix Pharmaceuticals, Inc.	tablet	NDANDA021361	2	0
Cardinal Health 418, Inc.United States	tablet	NDANDA021361	1	34
International Medication Systems, Ltd.United States	tablet	NDANDA021361	1	3

Bulk ingredient listings

Olon USA LLCItaly · 3 NDC
Granules Pharmaceuticals Inc.India · 2 NDC
MSN Laboratories Private Limited,India · 2 NDC
ALFASIGMA SPAItaly · 1 NDC
AX Pharmaceutical CorpCanada · 1 NDC
Aurobindo Pharma LimitedIndia · 1 NDC
CAMBREX PROFARMACO MILANO SRLItaly · 1 NDC
Chemeca Drugs Private LimitedIndia · 1 NDC
Clarochem Ireland LimitedIreland · 1 NDC
Hetero Drugs LimitedIndia · 1 NDC
Lupin LimitedIndia · 1 NDC
MEDISCA Inc.United States · 1 NDC
Optimus Drugs Private LimitedIndia · 1 NDC
Sun Pharmaceutical Industries LimitedIndia · 1 NDC
Willow Birch Pharma, LLCUnited States · 1 NDC

Orange Book patents

15 unexpired patents list rifaximin as the active ingredient, expiring between Sept 2027 and Oct 2029. Application holder: SALIX PHARMACEUTICALS INC.

Enquiry

Common questions

Who makes rifaximin?: 3 companies list rifaximin as a human prescription drug in the openFDA NDC Directory, led by Salix Pharmaceuticals, Inc., Cardinal Health 418, Inc., International Medication Systems, Ltd.. Each is the labeller, the firm named on the label; the product may be made at a site registered to another company.
Who supplies rifaximin active ingredient?: 15 companies list rifaximin as a bulk ingredient, including Olon USA LLC, Granules Pharmaceuticals Inc., MSN Laboratories Private Limited,, ALFASIGMA SPA.