Drug

Who makes sapropterin dihydrochloride?

10 companies list sapropterin dihydrochloride as a human prescription drug, including under the names Kuvan, JAVYGTOR, ZELVYSIA. Forms: powder, for solution; tablet. Routes: oral.

Labellers from the openFDA NDC Directory. A labeller is the firm named on the label, not necessarily the site that made the product, and a listing is not an FDA approval. Data as of 24 Sept 2026. Methodology

Companies listing sapropterin dihydrochloride

CompanyFormsApplicationNDCsRegistered sites
Par Health USA, LLCIndiapowder, for solution; tabletANDAANDA207200, ANDA207207, ANDA21002735
BioMarin International LimitedUnited Statespowder, for solution; tabletNDANDA022181, NDA20506532
Camber Pharmaceuticals, Inc.United Statespowder, for solution; tabletANDAANDA215420, ANDA21553431
Dr. Reddys Laboratories Limitedpowder, for solution; tabletANDAANDA207685, ANDA209452, ANDA21579830
NorthStar RxLLCpowder, for solution; tabletANDAANDA215420, ANDA21553430
Micro Labs LimitedIndiapowder, for solutionANDAANDA21951125
Aucta Pharmaceuticals, Inc.United Statespowder, for solutionANDAANDA21864522
TruPharma LLC.powder, for solutionANDAANDA21643220
Aurobindo Pharma LimitedIndiatabletANDAANDA21679716
Hikma Pharmaceuticals USA Inc.United StatestabletANDAANDA21879714

Bulk ingredient listings

Orange Book patents

2 unexpired patents list sapropterin dihydrochloride as the active ingredient, expiring between Nov 2032 and May 2033. Application holder: BIOMARIN PHARMACEUTICAL INC.

Enquiry

Common questions

Who makes sapropterin dihydrochloride?
10 companies list sapropterin dihydrochloride as a human prescription drug in the openFDA NDC Directory, led by Par Health USA, LLC, BioMarin International Limited, Camber Pharmaceuticals, Inc., Dr. Reddys Laboratories Limited, NorthStar RxLLC. Each is the labeller, the firm named on the label; the product may be made at a site registered to another company.
Is there a generic Kuvan?
9 companies list sapropterin dihydrochloride under an abbreviated new drug application (ANDA), the application type used for generics, and 1 under an NDA or BLA. Listing status is from the NDC Directory; it is not a statement of availability.
Who supplies sapropterin dihydrochloride active ingredient?
9 companies list sapropterin dihydrochloride as a bulk ingredient, including Biophore India Pharmaceuticals Private Limited, DOTTIKON EXCLUSIVE SYNTHESIS AG, Dipharma Francis Srl, Honour Lab Limited.