Patent cliff

Expiring in 2040

115 products lose patent protection in 2040. Deduplicated to one row per product and expiry, so the count reflects products rather than filings.
BrandActive ingredientApplication holderExpiryExcl.
AGAMREEVAMOROLONECATALYST PHARMACEUTICALS INC17 MarODE-450
AGAMREEVAMOROLONECATALYST PHARMACEUTICALS INC16 JulODE-450
AIRDUO DIGIHALERFLUTICASONE PROPIONATE; SALMETEROL XINAFOATETEVA PHARMACEUTICAL INDUSTRIES LTD20 Feb-
AIRDUO DIGIHALERFLUTICASONE PROPIONATE; SALMETEROL XINAFOATETEVA PHARMACEUTICAL INDUSTRIES LTD26 Mar-
AIRDUO DIGIHALERFLUTICASONE PROPIONATE; SALMETEROL XINAFOATETEVA PHARMACEUTICAL INDUSTRIES LTD06 Jul-
AIRDUO RESPICLICKFLUTICASONE PROPIONATE; SALMETEROL XINAFOATETEVA PHARMACEUTICAL INDUSTRIES LTD20 Feb-
ALYFTREKDEUTIVACAFTOR; TEZACAFTOR; VANZACAFTOR CALCIUMVERTEX PHARMACEUTICALS INC13 AugODE-536
AMBELVISTGADOQUATRANEBAYER HEALTHCARE PHARMACEUTICALS INC19 MayNCE
AMELUZAMINOLEVULINIC ACID HYDROCHLORIDEBIOFRONTERA INC15 OctD-194
ARMONAIR DIGIHALERFLUTICASONE PROPIONATETEVA PHARMACEUTICAL INDUSTRIES LTD20 Feb-
ARMONAIR DIGIHALERFLUTICASONE PROPIONATETEVA PHARMACEUTICAL INDUSTRIES LTD26 Mar-
ARMONAIR DIGIHALERFLUTICASONE PROPIONATETEVA PHARMACEUTICAL INDUSTRIES LTD06 Jul-
ARMONAIR RESPICLICKFLUTICASONE PROPIONATETEVA PHARMACEUTICAL INDUSTRIES LTD20 Feb-
ARYNTALISDEXAMFETAMINE DIMESYLATEAZURITY PHARMACEUTICALS INC16 Apr-
ARYNTALISDEXAMFETAMINE DIMESYLATEAZURITY PHARMACEUTICALS INC30 Aug-
AUVELITYBUPROPION HYDROCHLORIDE; DEXTROMETHORPHAN HYDROBROMIDEAXSOME THERAPEUTICS INC07 JanI-913
AUVELITYBUPROPION HYDROCHLORIDE; DEXTROMETHORPHAN HYDROBROMIDEAXSOME THERAPEUTICS INC05 JunI-913
AVMAPKI FAKZYNJA CO-PACK (COPACKAGED)AVUTOMETINIB POTASSIUM; DEFACTINIB HYDROCHLORIDEVERASTEM INC11 SeptODE-525
AYVAKITAVAPRITINIBBLUEPRINT MEDICINES CORP10 AprODE-434
BRINSUPRIBRENSOCATIBINSMED INC21 FebNCE
BRUKINSAZANUBRUTINIBBEONE MEDICINES USA INC10 JunODE*
BRYNOVINSITAGLIPTIN HYDROCHLORIDEAZURITY PHARMACEUTICALS INC23 Oct-
BYNFEZIA PENOCTREOTIDE ACETATESUN PHARMACEUTICAL INDUSTRIES LTD03 Nov-
CABENUVA KITCABOTEGRAVIR; RILPIVIRINEVIIV HEALTHCARE CO01 OctNCE
CABTREOADAPALENE; BENZOYL PEROXIDE; CLINDAMYCIN PHOSPHATEBAUSCH HEALTH US LLC31 JulNP
CABTREOADAPALENE; BENZOYL PEROXIDE; CLINDAMYCIN PHOSPHATEBAUSCH HEALTH US LLC28 DecNP
CAPLYTALUMATEPERONE TOSYLATEINTRA-CELLULAR THERAPIES INC07 JulM-319
CAPLYTALUMATEPERONE TOSYLATEINTRA-CELLULAR THERAPIES INC10 DecM-319
CARNEXIVCARBAMAZEPINELUNDBECK PHARMACEUTICALS LLC31 Jan-
COSELATRILACICLIB DIHYDROCHLORIDEPHARMACOSMOS AS13 NovNCE
DANZITENNILOTINIB TARTRATEAZURITY PHARMACEUTICALS INC18 Feb-
DAYBUETROFINETIDEACADIA PHARMACEUTICALS INC03 AugPED
DAYBUE STIXTROFINETIDEACADIA PHARMACEUTICALS INC03 AugPED
DUVYZATGIVINOSTAT HYDROCHLORIDEITALFARMACO SPA03 MayODE-473
DYANAVEL XR 10AMPHETAMINE; AMPHETAMINE ASPARTATE/DEXTROAMPHETAMINE SULFATETRIS PHARMA INC11 Feb-
DYANAVEL XR 15AMPHETAMINE; AMPHETAMINE ASPARTATE/DEXTROAMPHETAMINE SULFATETRIS PHARMA INC11 Feb-
DYANAVEL XR 20AMPHETAMINE; AMPHETAMINE ASPARTATE/DEXTROAMPHETAMINE SULFATETRIS PHARMA INC11 Feb-
DYANAVEL XR 5AMPHETAMINE; AMPHETAMINE ASPARTATE/DEXTROAMPHETAMINE SULFATETRIS PHARMA INC11 Feb-
ELIQUIS SPRINKLEAPIXABANBRISTOL MYERS SQUIBB CO22 NovPED
ELUCIREMGADOPICLENOLGUERBET17 JanNPP
EMERPHEDEPHEDRINE SULFATENEXUS PHARMACEUTICALS LLC16 May-
ENBUMYSTBUMETANIDECORSTASIS THERAPEUTICS INC04 Dec-
EPHEDRINE SULFATEEPHEDRINE SULFATEPH HEALTH LTD22 Jan-
EPRONTIATOPIRAMATEAZURITY PHARMACEUTICALS INC21 Aug-
EPSOLAYBENZOYL PEROXIDEMAYNE PHARMA LLC19 Feb-
EPSOLAYBENZOYL PEROXIDEMAYNE PHARMA LLC18 Aug-
EPSOLAYBENZOYL PEROXIDEMAYNE PHARMA LLC27 Dec-
ERLEADAAPALUTAMIDEJANSSEN BIOTECH INC30 Jan-
FARXIGADAPAGLIFLOZINASTRAZENECA AB18 JanPED
FARXIGADAPAGLIFLOZINASTRAZENECA AB09 MarPED
FARXIGADAPAGLIFLOZINASTRAZENECA AB09 SeptPED
FYARROSIROLIMUSAADI BIOSCIENCES INC28 OctODE-386
GEMTESAVIBEGRONSUMITOMO PHARMA AMERICA INC22 MarI-955
GENOSYLNITRIC OXIDEVERO BIOTECH INC22 Jul-
HETLIOZ LQTASIMELTEONVANDA PHARMACEUTICALS INC11 DecODE-329
IGALMIDEXMEDETOMIDINE HYDROCHLORIDEBIOXCEL THERAPEUTICS INC17 JulM-82
IMKELDIIMATINIB MESYLATESHORLA ONCOLOGY27 Apr-
INGREZZAVALBENAZINE TOSYLATENEUROCRINE BIOSCIENCES INC10 AugODE-440
INGREZZA SPRINKLEVALBENAZINE TOSYLATENEUROCRINE BIOSCIENCES INC10 AugI-925
INQOVICEDAZURIDINE; DECITABINETAIHO ONCOLOGY INC07 OctI-990
JOURNAVXSUZETRIGINEVERTEX PHARMACEUTICALS INC04 DecNCE
KONVOMEPOMEPRAZOLE; SODIUM BICARBONATEAZURITY PHARMACEUTICALS INC01 Mar-
KYGEVVIDOXECITINE; DOXRIBTIMINEUCB INC19 AugNCE
LASIX ONYUFUROSEMIDESQ INNOVATION INC03 Jan-
LAZCLUZELAZERTINIB MESYLATEJANSSEN BIOTECH INC14 MayNCE
LAZCLUZELAZERTINIB MESYLATEJANSSEN BIOTECH INC21 MayNCE
LIFYORLI (COPACKAGED)RELACORILANTCORCEPT THERAPEUTICS INC14 AprNCE
LILETTALEVONORGESTRELMEDICINES36007 SeptI-917
LIPFENDRAENLICITIDE DECANOATEMERCK SHARP AND DOHME LLC04 FebNCE
LIVMARLIMARALIXIBAT CHLORIDEMIRUM PHARMACEUTICALS INC12 FebI-938
LUMAKRASSOTORASIBAMGEN INC20 MayODE-507
LUMAKRASSOTORASIBAMGEN INC15 SeptODE-507
MOTPOLY XRLACOSAMIDEAUCTA PHARMACEUTICALS INC05 Jun-
MYCAPSSAOCTREOTIDE ACETATECHIESI FARMACEUTICI SPA28 DecODE-474
NEXLETOLBEMPEDOIC ACIDESPERION THERAPEUTICS INC19 JunI-943
NEXLIZETBEMPEDOIC ACID; EZETIMIBEESPERION THERAPEUTICS INC19 JunI-943
NUBEQADAROLUTAMIDEBAYER HEALTHCARE PHARMACEUTICALS INC02 JulI-971
OJJAARAMOMELOTINIB DIHYDROCHLORIDEGLAXOSMITHKLINE LLC02 DecODE-441
OPIPZAARIPIPRAZOLEXIAMEN LP PHARMACUETICAL CO LTD03 Nov-
OPZELURARUXOLITINIB PHOSPHATEINCYTE CORP10 JunNPP
OPZELURARUXOLITINIB PHOSPHATEINCYTE CORP28 JulNPP
OPZELURARUXOLITINIB PHOSPHATEINCYTE CORP04 SeptNPP
ORIAHNN (COPACKAGED)ELAGOLIX SODIUM,ESTRADIOL,NORETHINDRONE ACETATE; ELAGOLIX SODIUMABBVIE INC27 Aug-
ORILISSAELAGOLIX SODIUMABBVIE INC27 Aug-
ORLADEYOBEROTRALSTAT DIHYDROCHLORIDEBIOCRYST PHARMACEUTICALS INC01 MayPED
PEMAZYREPEMIGATINIBINCYTE CORP30 AugODE-404
PEMAZYREPEMIGATINIBINCYTE CORP03 OctODE-404
QAMZOVAMELOXICAMNANJING DELOVA BIOTECH CO LTD19 Jul-
QDOLOTRAMADOL HYDROCHLORIDEROSEMONT PHARMACEUTICALS LLC01 Sept-
QINLOCKRIPRETINIBDECIPHERA PHARMACEUTICALS LLC12 AugODE-298
QINLOCKRIPRETINIBDECIPHERA PHARMACEUTICALS LLC30 DecODE-298
RECORLEVLEVOKETOCONAZOLESTRONGBRIDGE DUBLIN LTD02 MarODE-385
RELYVRIOSODIUM PHENYLBUTYRATE; TAURURSODIOLAMYLYX PHARMACEUTICALS INC27 JulODE-411
REYVOWLASMIDITAN SUCCINATEELI LILLY AND CO06 Jul-
ROMVIMZAVIMSELTINIBDECIPHERA PHARMACEUTICALS LLC03 FebNCE
SCEMBLIXASCIMINIB HYDROCHLORIDENOVARTIS PHARMACEUTICALS CORP14 MayODE-499
SCEMBLIXASCIMINIB HYDROCHLORIDENOVARTIS PHARMACEUTICALS CORP17 MayODE-499
SOFDRASOFPIRONIUM BROMIDEBOTANIX SB INC22 MayNCE
SPRAVATOESKETAMINE HYDROCHLORIDEJANSSEN PHARMACEUTICALS INC18 FebI-959
SUBVENITELAMOTRIGINEOWP PHARMACEUTICALS INC29 May-
SUNOSISOLRIAMFETOL HYDROCHLORIDEAXSOME MALTA LTD19 MarODE-254
SYMBRAVOMELOXICAM; RIZATRIPTAN BENZOATEAXSOME THERAPEUTICS INC28 MayNP
SYMPAZANCLOBAZAMCOSETTE PHARMACEUTICALS INC31 Jan-
TLANDOTESTOSTERONE UNDECANOATEVERITY PHARMACEUTICALS INC16 Oct-
TWYNEOBENZOYL PEROXIDE; TRETINOINMAYNE PHARMA LLC27 Dec-
TYMLOSABALOPARATIDERADIUS HEALTH INC10 Jan-
UZEDYRISPERIDONETEVA NEUROSCIENCE INC11 SeptNP
VANRAFIAATRASENTAN HYDROCHLORIDENOVARTIS PHARMACEUTICALS CORP16 DecNCE
VYALEVFOSCARBIDOPA; FOSLEVODOPAABBVIE INC10 JunNP
WAYRILZRILZABRUTINIBGENZYME CORP13 OctODE-552
WEGOVYSEMAGLUTIDENOVO NORDISK INC13 MayI-973
WEGOVY FLEXTOUCHSEMAGLUTIDENOVO NORDISK INC13 MayI-973
XIPERETRIAMCINOLONE ACETONIDEBAUSCH AND LOMB INC16 Apr-
YEZTUGOLENACAPAVIR SODIUMGILEAD SCIENCES INC25 NovNP
ZEPZELCALURBINECTEDINJAZZ PHARMACEUTICALS IRELAND LTD29 MayI-977
Provenance

Source: FDA Orange Book patent and exclusivity files. Rows carrying an exclusivity code have a separate regulatory exclusivity that can outlast the patent shown. Patent expiry alone does not determine when a generic can launch: paediatric extensions, 30-month stays and settlement agreements frequently move the effective date. Delisted patents are excluded.