Patent cliff

Expiring in 2039

164 products lose patent protection in 2039. Deduplicated to one row per product and expiry, so the count reflects products rather than filings.
BrandActive ingredientApplication holderExpiryExcl.
ADRENALINEPINEPHRINEPH HEALTH LTD21 Mar-
AIRDUO DIGIHALERFLUTICASONE PROPIONATE; SALMETEROL XINAFOATETEVA PHARMACEUTICAL INDUSTRIES LTD20 Aug-
AIRDUO DIGIHALERFLUTICASONE PROPIONATE; SALMETEROL XINAFOATETEVA PHARMACEUTICAL INDUSTRIES LTD26 Sept-
AIRDUO RESPICLICKFLUTICASONE PROPIONATE; SALMETEROL XINAFOATETEVA PHARMACEUTICAL INDUSTRIES LTD20 Aug-
ALYFTREKDEUTIVACAFTOR; TEZACAFTOR; VANZACAFTOR CALCIUMVERTEX PHARMACEUTICALS INC14 FebODE-536
AMBELVISTGADOQUATRANEBAYER HEALTHCARE PHARMACEUTICALS INC21 NovNCE
ANGIOMAX RTUBIVALIRUDINMAIA PHARMACEUTICALS INC20 May-
ANJESOMELOXICAMBAUDAX BIO INC08 Mar-
ANNOVERAETHINYL ESTRADIOL; SEGESTERONE ACETATEMAYNE PHARMA LLC01 Feb-
ANNOVERAETHINYL ESTRADIOL; SEGESTERONE ACETATEMAYNE PHARMA LLC21 Jun-
ARISTADAARIPIPRAZOLE LAUROXILALKERMES INC06 Apr-
ARISTADA INITIO KITARIPIPRAZOLE LAUROXILALKERMES INC06 Apr-
ARMONAIR DIGIHALERFLUTICASONE PROPIONATETEVA PHARMACEUTICAL INDUSTRIES LTD20 Aug-
ARMONAIR DIGIHALERFLUTICASONE PROPIONATETEVA PHARMACEUTICAL INDUSTRIES LTD26 Sept-
ARMONAIR RESPICLICKFLUTICASONE PROPIONATETEVA PHARMACEUTICAL INDUSTRIES LTD20 Aug-
ATTRUBYACORAMIDIS HYDROCHLORIDEBRIDGEBIO PHARMA INC22 MarODE-506
ATTRUBYACORAMIDIS HYDROCHLORIDEBRIDGEBIO PHARMA INC16 AugODE-506
ATZUMIDIHYDROERGOTAMINE MESYLATESATSUMA PHARMACEUTICALS INC11 DecNP
AZMIROTESTOSTERONE CYPIONATEAZURITY PHARMACEUTICALS INC25 Mar-
BAQSIMIGLUCAGONAMPHASTAR PHARMACEUTICALS INC23 SeptNPP
BEQALZISONROTOCLAXBEONE MEDICINES USA INC29 AprNCE
BREKIYA (AUTOINJECTOR)DIHYDROERGOTAMINE MESYLATEAMNEAL PHARMACEUTICALS LLC26 Feb-
BREKIYA (AUTOINJECTOR)DIHYDROERGOTAMINE MESYLATEAMNEAL PHARMACEUTICALS LLC20 Mar-
BREKIYA (AUTOINJECTOR)DIHYDROERGOTAMINE MESYLATEAMNEAL PHARMACEUTICALS LLC27 May-
BREKIYA (AUTOINJECTOR)DIHYDROERGOTAMINE MESYLATEAMNEAL PHARMACEUTICALS LLC30 Jun-
BREKIYA (AUTOINJECTOR)DIHYDROERGOTAMINE MESYLATEAMNEAL PHARMACEUTICALS LLC24 Aug-
BREXAFEMMEIBREXAFUNGERP CITRATEGLAXOSMITHKLINE LLC10 JunGAIN
BRINSUPRIBRENSOCATIBINSMED INC01 MarNCE
BRUKINSAZANUBRUTINIBBEONE MEDICINES USA INC24 JunODE-467
BYLVAYODEVIXIBATIPSEN BIOPHARMACEUTICALS INC20 JunODE-436
CAMCEVI ETMLEUPROLIDE MESYLATEACCORD BIOPHARMA INC01 JanNS
CAMCEVI KITLEUPROLIDE MESYLATEACCORD BIOPHARMA INC01 Jan-
CAPLYTALUMATEPERONE TOSYLATEINTRA-CELLULAR THERAPIES INC15 MarM-319
CAPLYTALUMATEPERONE TOSYLATEINTRA-CELLULAR THERAPIES INC30 AugM-319
CAPLYTALUMATEPERONE TOSYLATEINTRA-CELLULAR THERAPIES INC27 OctM-319
COBENFYTROSPIUM CHLORIDE; XANOMELINE TARTRATEBRISTOL-MYERS SQUIBB CO27 SeptNCE
COBENFYTROSPIUM CHLORIDE; XANOMELINE TARTRATEBRISTOL-MYERS SQUIBB CO29 OctNCE
COMBOGESICACETAMINOPHEN; IBUPROFENAFT PHARMACEUTICALS US INC27 FebNP
CONTEPOFOSFOMYCIN DISODIUMMEITHEAL PHARMACEUTICALS INC30 JanGAIN
COSELATRILACICLIB DIHYDROCHLORIDEPHARMACOSMOS AS23 JulNCE
CUVRIORTRIENTINE TETRAHYDROCHLORIDEORPHALAN SA03 MayODE-401
CYKLXARTICAINE HYDROCHLORIDETHEA PHARMA INC27 MarNP
DEXYCU KITDEXAMETHASONEEYEPOINT PHARMACEUTICALS INC23 Jun-
DHIVYCARBIDOPA; LEVODOPAAVION PHARMACEUTICALS LLC28 Mar-
EKTERLYSEBETRALSTATKALVISTA PHARMACEUTICALS LTD26 JanODE-534
ELCYSCYSTEINE HYDROCHLORIDEEXELA PHARMA SCIENCES LLC15 Jan-
ELUCIREMGADOPICLENOLGUERBET06 AugNPP
EMROSIMINOCYCLINE HYDROCHLORIDEJOURNEY MEDICAL CORP07 JanNP
EOHILIABUDESONIDETAKEDA PHARMACEUTICALS USA INC10 JanODE-466
EPIDIOLEXCANNABIDIOLJAZZ PHARMACEUTICALS RESEARCH UK LTD26 AprODE-326
ERZOFRIPALIPERIDONE PALMITATELUYE INNOMIND PHARMA (SHIJIAZHUANG) CO LTD24 Sept-
FARXIGADAPAGLIFLOZINASTRAZENECA AB18 JulPED
FILSUVEZBIRCH TRITERPENESCHIESI FARMACEUTICI SPA04 JanODE-460
FOCINVEZFOSAPREPITANT DIMEGLUMINESTERISCIENCE PTE LTD11 Jan-
FOTIVDATIVOZANIB HYDROCHLORIDEAVEO PHARMACEUTICALS INC05 NovNCE
GALAFOLDMIGALASTAT HYDROCHLORIDEAMICUS THERAPEUTICS US LLC06 Feb-
GALAFOLDMIGALASTAT HYDROCHLORIDEAMICUS THERAPEUTICS US LLC16 Feb-
GALAFOLDMIGALASTAT HYDROCHLORIDEAMICUS THERAPEUTICS US LLC20 Feb-
GALAFOLDMIGALASTAT HYDROCHLORIDEAMICUS THERAPEUTICS US LLC17 Mar-
GALAFOLDMIGALASTAT HYDROCHLORIDEAMICUS THERAPEUTICS US LLC25 Mar-
GAVRETOPRALSETINIBRIGEL PHARMACEUTICALS INC03 AprODE-340
ICOTYDEICOTROKINRA HYDROCHLORIDEJANSSEN BIOTECH INC12 JulNCE
IGALMIDEXMEDETOMIDINE HYDROCHLORIDEBIOXCEL THERAPEUTICS INC26 JunM-82
IHEEZOCHLOROPROCAINE HYDROCHLORIDEHARROW EYE LLC14 May-
IMBRUVICAIBRUTINIBPHARMACYCLICS LLC14 JunPED
INGREZZAVALBENAZINE TOSYLATENEUROCRINE BIOSCIENCES INC14 AugODE-440
INGREZZA SPRINKLEVALBENAZINE TOSYLATENEUROCRINE BIOSCIENCES INC14 AugI-925
INLURIYOIMLUNESTRANT TOSYLATEELI LILLY AND CO11 JulNCE
INREBICFEDRATINIB HYDROCHLORIDEBRISTOL-MYERS SQUIBB CO24 SeptODE-259
JATENZOTESTOSTERONE UNDECANOATETOLMAR INC12 Apr-
JAYPIRCAPIRTOBRUTINIBLOXO ONCOLOGY INC29 JulODE-518
KATERZIAAMLODIPINE BENZOATEAZURITY PHARMACEUTICALS INC11 Apr-
KHAPZORYLEVOLEUCOVORINACROTECH BIOPHARMA INC25 Mar-
KONVOMEPOMEPRAZOLE; SODIUM BICARBONATEAZURITY PHARMACEUTICALS INC16 Jul-
LIFYORLI (COPACKAGED)RELACORILANTCORCEPT THERAPEUTICS INC18 DecNCE
LIKMEZMETRONIDAZOLESAPTALIS PHARMACEUTICALS LLC16 Jan-
LIKMEZMETRONIDAZOLESAPTALIS PHARMACEUTICALS LLC04 Oct-
LUMAKRASSOTORASIBAMGEN INC18 NovODE-507
LUMASONSULFUR HEXAFLUORIDE LIPID-TYPE A MICROSPHERESBRACCO DIAGNOSTICS INC15 May-
LUTATHERALUTETIUM LU 177 DOTATATEADVANCED ACCELERATOR APPLICATIONS USA INC25 JanPED
LYNKUETELINZANETANTBAYER HEALTHCARE PHARMACEUTICALS INC13 MarNCE
LYTGOBIFUTIBATINIBTAIHO ONCOLOGY INC05 NovODE*
LYVISPAHBACLOFENSTRIDES PHARMA INTERNATIONAL AG29 Jul-
METAXALONEMETAXALONEPRIMUS PHARMACEUTICALS INC29 Jul-
MOUNJAROTIRZEPATIDEELI LILLY AND CO14 JunNPP
MOUNJAROTIRZEPATIDEELI LILLY AND CO22 JulNPP
MOUNJARO (AUTOINJECTOR)TIRZEPATIDEELI LILLY AND CO14 JunNPP
MOUNJARO (AUTOINJECTOR)TIRZEPATIDEELI LILLY AND CO22 JulNCE
MOUNJARO KWIKPENTIRZEPATIDEELI LILLY AND CO22 JulNPP
MYHIBBINMYCOPHENOLATE MOFETILAZURITY PHARMACEUTICALS INC16 Aug-
MYQORZOAFICAMTENCYTOKINETICS INC18 JanNCE
NEFFYEPINEPHRINEARS PHARMACEUTICALS OPERATIONS INC06 Feb-
NOREPINEPHRINE BITARTRATE IN 0.9% SODIUM CHLORIDENOREPINEPHRINE BITARTRATEINFORLIFE SA26 Apr-
NOURESSCYSTEINE HYDROCHLORIDEBAXTER HEALTHCARE CORP15 Jan-
NOURESSCYSTEINE HYDROCHLORIDEBAXTER HEALTHCARE CORP02 Mar-
NOURESSCYSTEINE HYDROCHLORIDEBAXTER HEALTHCARE CORP15 Mar-
NUPLAZIDPIMAVANSERIN TARTRATEACADIA PHARMACEUTICALS INC27 FebPED
NURTEC ODTRIMEGEPANT SULFATEPFIZER INC25 Mar-
OGSIVEONIROGACESTAT HYDROBROMIDESPRINGWORKS THERAPEUTICS INC09 AugODE*
OJJAARAMOMELOTINIB DIHYDROCHLORIDEGLAXOSMITHKLINE LLC21 AugODE-441
OMLONTIOMIDENEPAG ISOPROPYLOCUVEX THERAPEUTICS INC16 JulNCE
ORIAHNN (COPACKAGED)ELAGOLIX SODIUM,ESTRADIOL,NORETHINDRONE ACETATE; ELAGOLIX SODIUMABBVIE INC23 Jul-
ORILISSAELAGOLIX SODIUMABBVIE INC23 Jul-
ORLADEYOBEROTRALSTAT DIHYDROCHLORIDEBIOCRYST PHARMACEUTICALS INC01 NovPED
ORLYNVAHPROBENECID; SULOPENEM ETZADROXILITERUM THERAPEUTICS US LTD01 AprGAIN
ORLYNVAHPROBENECID; SULOPENEM ETZADROXILITERUM THERAPEUTICS US LTD23 DecGAIN
OZEMPICSEMAGLUTIDENOVO NORDISK INC01 FebI-976
OZOBAXBACLOFENMETACEL PHARMACEUTICALS LLC30 Aug-
PALSONIFYPALTUSOTINE HYDROCHLORIDECRINETICS PHARMACEUTICALS INC16 JanODE-537
PEDMARKSODIUM THIOSULFATEFENNEC PHARMACEUTICALS INC01 JulODE-384
PEMAZYREPEMIGATINIBINCYTE CORP03 MayODE-404
POTASSIUM CHLORIDEPOTASSIUM CHLORIDEGENUS LIFE SCIENCES INC07 Mar-
POTASSIUM PHOSPHATESPOTASSIUM PHOSPHATE, DIBASIC; POTASSIUM PHOSPHATE, MONOBASICCMP DEVELOPMENT LLC19 Apr-
QULIPTAATOGEPANTABBVIE INC06 JunNCE
QVAR REDIHALERBECLOMETHASONE DIPROPIONATENORTON WATERFORD LTD25 Jan-
QVAR REDIHALERBECLOMETHASONE DIPROPIONATENORTON WATERFORD LTD21 Jul-
RADICAVA ORSEDARAVONESHIONOGI INC01 NovODE-144
RETEVMOSELPERCATINIBELI LILLY AND CO10 AprPED
REZLIDHIAOLUTASIDENIBRIGEL PHARMACEUTICALS INC16 MayODE-413
REZLIDHIAOLUTASIDENIBRIGEL PHARMACEUTICALS INC17 JulODE-413
REZLIDHIAOLUTASIDENIBRIGEL PHARMACEUTICALS INC12 NovODE-413
ROCURONIUM BROMIDEROCURONIUM BROMIDEB BRAUN MEDICAL INC22 Jul-
ROMVIMZAVIMSELTINIBDECIPHERA PHARMACEUTICALS LLC23 DecNCE
RYALTRISMOMETASONE FUROATE; OLOPATADINE HYDROCHLORIDEGLENMARK SPECIALTY SA08 AprNPP
RYTELOIMETELSTAT SODIUMGERON CORP16 JunODE-482
RYZUMVIPHENTOLAMINE MESYLATEFAMYGEN LIFE SCIENCES INC25 OctNP
SOTALOL HYDROCHLORIDESOTALOL HYDROCHLORIDEALTATHERA PHARMACEUTICALS LLC05 Apr-
SOTALOL HYDROCHLORIDESOTALOL HYDROCHLORIDEALTATHERA PHARMACEUTICALS LLC21 Aug-
SPY AGENT GREEN KITINDOCYANINE GREENNOVADAQ TECHNOLOGIES ULC14 JulI-911
SUNLENCALENACAPAVIR SODIUMGILEAD SCIENCES INC15 JulNCE
SUNOSISOLRIAMFETOL HYDROCHLORIDEAXSOME MALTA LTD06 MarODE-254
SYMPAZANCLOBAZAMCOSETTE PHARMACEUTICALS INC05 Sept-
TAVNEOSAVACOPANCHEMOCENTRYX INC27 NovODE-377
TIBSOVOIVOSIDENIBSERVIER PHARMACEUTICALS LLC07 JunODE-447
TIROSINT-SOLLEVOTHYROXINE SODIUMIBSA INSTITUT BIOCHIMIQUE SA17 Sept-
TLANDOTESTOSTERONE UNDECANOATEVERITY PHARMACEUTICALS INC21 Feb-
TRUDHESADIHYDROERGOTAMINE MESYLATEIMPEL PHARMACEUTICALS LLC04 Jan-
UPNEEQOXYMETAZOLINE HYDROCHLORIDERVL PHARMACEUTICALS INC16 Dec-
VABOMEREMEROPENEM; VABORBACTAMREMPEX PHARMACEUTICALS INC A WHOLLY OWNED SUB OF MELINTA THERAPEUTICS LLC06 AprGAIN
VEKLURYREMDESIVIRGILEAD SCIENCES INC10 JanPED
VEVYECYCLOSPORINEHARROW EYE LLC11 OctNP
VIGAFYDEVIGABATRINPYROS PHARMACEUTICALS INC16 Aug-
VIZZACECLIDINE HYDROCHLORIDELENZ THERAPEUTICS INC08 OctNCE
VORANIGOVORASIDENIBSERVIER PHARMACEUTICALS LLC16 JanODE-491
VOSTALLYRAMIPRILROSEMONT PHARMACEUTICALS HOLDINGS INC16 Aug-
VTAMATAPINAROFORGANON LLC13 NovI-956
VTAMATAPINAROFORGANON LLC18 DecI-956
VUITYPILOCARPINE HYDROCHLORIDEABBVIE INC24 AprD-187
WEGOVYSEMAGLUTIDENOVO NORDISK INC01 FebNP
WYNZORABETAMETHASONE DIPROPIONATE; CALCIPOTRIENEMC2 THERAPEUTICS LTD18 Mar-
XCOPRICENOBAMATESK LIFE SCIENCE INC16 Jun-
XOFLUZABALOXAVIR MARBOXILGENENTECH INC09 OctM-187
YEZTUGOLENACAPAVIR SODIUMGILEAD SCIENCES INC15 JulNP
YUPELRIREVEFENACINMYLAN IRELAND LTD29 Aug-
YUPELRIREVEFENACINMYLAN IRELAND LTD23 Oct-
ZEGFROVYSUNVOZERTINIBDIZAL PHARMACEUTICAL CO LTD28 JanNCE
ZEJULANIRAPARIB TOSYLATEGLAXOSMITHKLINE LLC25 Jan-
ZEPBOUNDTIRZEPATIDEELI LILLY AND CO14 JunI-958
ZEPBOUNDTIRZEPATIDEELI LILLY AND CO22 JulI-958
ZEPBOUND (AUTOINJECTOR)TIRZEPATIDEELI LILLY AND CO14 JunI-958
ZEPBOUND (AUTOINJECTOR)TIRZEPATIDEELI LILLY AND CO22 JulI-958
ZEPBOUND KWIKPENTIRZEPATIDEELI LILLY AND CO22 JulI-958
ZIMHINALOXONE HYDROCHLORIDEZMI PHARMA INC24 May-
ZURNAI (AUTOINJECTOR)NALMEFENE HYDROCHLORIDEKNOA PHARMA LLC05 NovNP
Provenance

Source: FDA Orange Book patent and exclusivity files. Rows carrying an exclusivity code have a separate regulatory exclusivity that can outlast the patent shown. Patent expiry alone does not determine when a generic can launch: paediatric extensions, 30-month stays and settlement agreements frequently move the effective date. Delisted patents are excluded.