Patent cliff

Expiring in 2041

117 products lose patent protection in 2041. Deduplicated to one row per product and expiry, so the count reflects products rather than filings.
BrandActive ingredientApplication holderExpiryExcl.
ACTHAR GELCORTICOTROPINMALLINCKRODT PHARMACEUTICALS IRELAND LTD18 Jul-
ACTHAR GEL (AUTOINJECTOR)CORTICOTROPINMALLINCKRODT PHARMACEUTICALS IRELAND LTD18 Jul-
ADVIL DUAL ACTION WITH ACETAMINOPHENACETAMINOPHEN; IBUPROFENHALEON US HOLDINGS LLC09 Jul-
AIRDUO DIGIHALERFLUTICASONE PROPIONATE; SALMETEROL XINAFOATETEVA PHARMACEUTICAL INDUSTRIES LTD06 Jan-
APHEXDAMOTIXAFORTIDE ACETATEAYRMID PHARMA LTD29 DecODE-442
AQVESMEMITAPIVAT SULFATEAGIOS PHARMACEUTICALS INC31 JulODE-522
ARBLILOSARTAN POTASSIUMSCIENTURE LLC07 Oct-
ARMONAIR DIGIHALERFLUTICASONE PROPIONATETEVA PHARMACEUTICAL INDUSTRIES LTD06 Jan-
ATZUMIDIHYDROERGOTAMINE MESYLATESATSUMA PHARMACEUTICALS INC12 OctNP
AURLUMYNILOPROSTBTG INTERNATIONAL INC06 AugODE-465
AUSTEDO XRDEUTETRABENAZINETEVA NEUROSCIENCE INC10 Jun-
AUVELITYBUPROPION HYDROCHLORIDE; DEXTROMETHORPHAN HYDROBROMIDEAXSOME THERAPEUTICS INC01 DecI-913
BRENZAVVYBEXAGLIFLOZINTHERACOSBIO LLC05 OctNCE
BYLVAYODEVIXIBATIPSEN BIOPHARMACEUTICALS INC12 NovODE-436
BYNFEZIA PENOCTREOTIDE ACETATESUN PHARMACEUTICAL INDUSTRIES LTD29 Dec-
CAVHANZANILOTINIBFLEX PHARMA LLC29 Jan-
CAVHANZANILOTINIBFLEX PHARMA LLC30 Apr-
CRENESSITYCRINECERFONTNEUROCRINE BIOSCIENCES INC09 JunODE-503
CREXONTCARBIDOPA; LEVODOPAIMPAX LABORATORIES LLC21 DecNP
DAPZURA RTDAPTOMYCINBAXTER HEALTHCARE CORP11 Mar-
DAYBUETROFINETIDEACADIA PHARMACEUTICALS INC03 FebPED
DAYBUE STIXTROFINETIDEACADIA PHARMACEUTICALS INC03 FebPED
DETECTNETCOPPER CU-64 DOTATATECURIUM US LLC03 SeptODE-317
DEXTENZADEXAMETHASONEOCULAR THERAPEUTIX INC26 AprNPP
ELIGARD KITLEUPROLIDE ACETATETOLMAR INC22 Dec-
ELIQUIS SPRINKLEAPIXABANBRISTOL MYERS SQUIBB CO22 MayPED
EPIDIOLEXCANNABIDIOLJAZZ PHARMACEUTICALS RESEARCH UK LTD01 MarODE-326
EPSOLAYBENZOYL PEROXIDEMAYNE PHARMA LLC23 May-
ERLEADAAPALUTAMIDEJANSSEN BIOTECH INC14 Jan-
EVRYSDIRISDIPLAMGENENTECH INC15 AprM-270
EXPARELBUPIVACAINEPACIRA PHARMACEUTICALS INC22 JanI-929
FABHALTAIPTACOPAN HYDROCHLORIDENOVARTIS PHARMACEUTICALS CORP17 MayODE-524
FABHALTAIPTACOPAN HYDROCHLORIDENOVARTIS PHARMACEUTICALS CORP25 MayODE-524
FABHALTAIPTACOPAN HYDROCHLORIDENOVARTIS PHARMACEUTICALS CORP15 JulODE-524
FARXIGADAPAGLIFLOZINASTRAZENECA AB01 AprPED
FARXIGADAPAGLIFLOZINASTRAZENECA AB01 OctPED
FEMLYVETHINYL ESTRADIOL; NORETHINDRONE ACETATEMILLICENT MANUFACTURING PR LLC24 JunNP
FENSOLVI KITLEUPROLIDE ACETATETOLMAR INTERNATIONAL LTD22 Dec-
GALAFOLDMIGALASTAT HYDROCHLORIDEAMICUS THERAPEUTICS US LLC23 May-
GOMEKLIMIRDAMETINIBSPRINGWORKS THERAPEUTICS INC17 FebODE-488
HERNEXEOSZONGERTINIBBOEHRINGER INGELHEIM PHARMACEUTICALS INC21 JulNCE
HETLIOZTASIMELTEONVANDA PHARMACEUTICALS INC21 FebODE-330
HETLIOZ LQTASIMELTEONVANDA PHARMACEUTICALS INC21 FebODE-329
ICOTYDEICOTROKINRA HYDROCHLORIDEJANSSEN BIOTECH INC14 JanNCE
ICOTYDEICOTROKINRA HYDROCHLORIDEJANSSEN BIOTECH INC19 NovNCE
INQOVICEDAZURIDINE; DECITABINETAIHO ONCOLOGY INC24 FebI-990
INVEGA HAFYERAPALIPERIDONE PALMITATEJANSSEN PHARMACEUTICALS INC07 May-
INVEGA HAFYERAPALIPERIDONE PALMITATEJANSSEN PHARMACEUTICALS INC24 Nov-
JAYPIRCAPIRTOBRUTINIBLOXO ONCOLOGY INC14 SeptODE-518
JIDEYTROZIDESAMTINIBNUVALENT INC05 May-
JUXTAPIDLOMITAPIDE MESYLATECHIESI FARMACEUTICI SPA29 JulNS
KRAZATIADAGRASIBBRISTOL MYERS SQUIBB CO05 FebODE-352
KRAZATIADAGRASIBBRISTOL MYERS SQUIBB CO10 SeptODE-352
KYPROLISCARFILZOMIBONYX PHARMACEUTICALS INC A WHOLLY OWNED SUB OF AMGEN INC29 AprPED
KYPROLISCARFILZOMIBONYX PHARMACEUTICALS INC A WHOLLY OWNED SUB OF AMGEN INC29 OctPED
KYZATREXTESTOSTERONE UNDECANOATEMARIUS PHARMACEUTICALS INC29 Mar-
LAZCLUZELAZERTINIB MESYLATEJANSSEN BIOTECH INC13 AprNCE
LAZCLUZELAZERTINIB MESYLATEJANSSEN BIOTECH INC01 AugNCE
LEQSELVIDEURUXOLITINIB PHOSPHATESUN PHARMACEUTICAL INDUSTRIES INC21 MayNCE
LIFYORLI (COPACKAGED)RELACORILANTCORCEPT THERAPEUTICS INC26 MayNCE
LIFYORLI (COPACKAGED)RELACORILANTCORCEPT THERAPEUTICS INC22 DecNCE
LITFULORITLECITINIB TOSYLATEPFIZER INC17 OctNCE
LYBALVIOLANZAPINE; SAMIDORPHAN L-MALATEALKERMES INC12 NovNCE
LYNPARZAOLAPARIBASTRAZENECA PHARMACEUTICALS LP25 OctODE-306
LYVISPAHBACLOFENSTRIDES PHARMA INTERNATIONAL AG29 Sept-
MAVENCLADCLADRIBINEEMD SERONO INC10 Sept-
MIPLYFFAARIMOCLOMOL CITRATEZEVRA DENMARK AS19 NovODE-496
MOUNJAROTIRZEPATIDEELI LILLY AND CO30 DecNPP
MOUNJARO (AUTOINJECTOR)TIRZEPATIDEELI LILLY AND CO30 DecNPP
MOUNJARO KWIKPENTIRZEPATIDEELI LILLY AND CO30 DecNPP
MULTRYSCUPRIC SULFATE; MANGANESE SULFATE; SELENIOUS ACID; ZINC SULFATEAMERICAN REGENT INC01 Jul-
NOREPINEPHRINE BITARTRATE IN 5% DEXTROSENOREPINEPHRINE BITARTRATEBAXTER HEALTHCARE CORP08 Mar-
NORLIQVAAMLODIPINE BESYLATECMP DEVELOPMENT LLC24 Feb-
ONYDA XRCLONIDINE HYDROCHLORIDETRIS PHARMA INC28 Jul-
OPIPZAARIPIPRAZOLEXIAMEN LP PHARMACUETICAL CO LTD15 Dec-
OPZELURARUXOLITINIB PHOSPHATEINCYTE CORP05 MayNPP
OZEMPICSEMAGLUTIDENOVO NORDISK INC17 Feb-
PALSONIFYPALTUSOTINE HYDROCHLORIDECRINETICS PHARMACEUTICALS INC07 SeptODE-537
PAXLOVID (COPACKAGED)NIRMATRELVIR; RITONAVIRPFIZER INC05 AugNCE
PAXLOVID (COPACKAGED)NIRMATRELVIR; RITONAVIRPFIZER INC31 OctNCE
PHYRAGODASATINIBHANDA THERAPEUTICS LLC22 JanM-307
PLUVICTOLUTETIUM LU-177 VIPIVOTIDE TETRAXETANNOVARTIS PHARMACEUTICALS CORP18 SeptI-965
POSIMIRBUPIVACAINEINNOCOLL PHARMACEUTICALS LTD12 Jan-
POSLUMAFLOTUFOLASTAT F-18 GALLIUMBLUE EARTH DIAGNOSTICS LTD27 NovNCE
POTASSIUM PHOSPHATES IN 0.9% SODIUM CHLORIDEPOTASSIUM PHOSPHATE, DIBASIC; POTASSIUM PHOSPHATE, MONOBASICFRESENIUS KABI USA LLC12 Oct-
PYRUKYNDMITAPIVAT SULFATEAGIOS PHARMACEUTICALS INC31 JulODE-392
QINLOCKRIPRETINIBDECIPHERA PHARMACEUTICALS LLC08 FebODE-298
QULIPTAATOGEPANTABBVIE INC29 JulNCE
QVAR REDIHALERBECLOMETHASONE DIPROPIONATENORTON WATERFORD LTD05 May-
QVAR REDIHALERBECLOMETHASONE DIPROPIONATENORTON WATERFORD LTD19 Aug-
RADICAVA ORSEDARAVONESHIONOGI INC12 NovODE-144
REZENOPYNALOXONE HYDROCHLORIDESCIENTURE LLC05 FebNP
SELENIOUS ACIDSELENIOUS ACIDAMERICAN REGENT INC01 Jul-
SOLOSECSECNIDAZOLEEVOFEM INC11 DecGAIN
SUCCINYLCHOLINE CHLORIDESUCCINYLCHOLINE CHLORIDEHIKMA PHARMACEUTICALS USA INC02 Nov-
SUNLENCALENACAPAVIR SODIUMGILEAD SCIENCES INC28 AugNCE
SYMBRAVOMELOXICAM; RIZATRIPTAN BENZOATEAXSOME THERAPEUTICS INC29 DecNP
TEPYLUTETHIOTEPASHORLA PHARMA LTD16 Aug-
TEZRULYTERAZOSIN HYDROCHLORIDENOVITIUM PHARMA LLC01 Feb-
TLANDOTESTOSTERONE UNDECANOATEVERITY PHARMACEUTICALS INC28 Apr-
TRALEMENTCUPRIC SULFATE; MANGANESE SULFATE; SELENIOUS ACID; ZINC SULFATEAMERICAN REGENT INC01 Jul-
TWYNEOBENZOYL PEROXIDE; TRETINOINMAYNE PHARMA LLC23 May-
UBRELVYUBROGEPANTABBVIE INC22 Dec-
VANRAFIAATRASENTAN HYDROCHLORIDENOVARTIS PHARMACEUTICALS CORP02 MarNCE
VEKLURYREMDESIVIRGILEAD SCIENCES INC28 MayPED
VEKLURYREMDESIVIRGILEAD SCIENCES INC28 NovPED
VYLEESI (AUTOINJECTOR)BREMELANOTIDE ACETATECOSETTE PHARMACEUTICALS INC29 Apr-
WAYRILZRILZABRUTINIBGENZYME CORP20 FebODE-552
WEGOVYSEMAGLUTIDENOVO NORDISK INC17 FebI-973
WEGOVY HDSEMAGLUTIDENOVO NORDISK INC17 FebNS
XIFYRMMELOXICAMAZURITY PHARMACEUTICALS INC31 Jul-
XOFLUZABALOXAVIR MARBOXILGENENTECH INC21 AprM-187
XROMIHYDROXYUREANOVA LABORATORIES LTD23 DecODE-470
XYWAVCALCIUM OXYBATE; MAGNESIUM OXYBATE; POTASSIUM OXYBATE; SODIUM OXYBATEJAZZ PHARMACEUTICALS IRELAND LTD22 FebODE-369
YCANTHCANTHARIDINVERRICA PHARMACEUTICALS INC19 FebNCE
ZIMHINALOXONE HYDROCHLORIDEZMI PHARMA INC14 Jun-
ZORYVEROFLUMILASTARCUTIS BIOTHERAPEUTICS INC03 DecI-969
Provenance

Source: FDA Orange Book patent and exclusivity files. Rows carrying an exclusivity code have a separate regulatory exclusivity that can outlast the patent shown. Patent expiry alone does not determine when a generic can launch: paediatric extensions, 30-month stays and settlement agreements frequently move the effective date. Delisted patents are excluded.