Patent cliff

Expiring in 2038

152 products lose patent protection in 2038. Deduplicated to one row per product and expiry, so the count reflects products rather than filings.
BrandActive ingredientApplication holderExpiryExcl.
ADHANSIA XRMETHYLPHENIDATE HYDROCHLORIDEKNOA PHARMA LLC19 Nov-
ADLARITYDONEPEZIL HYDROCHLORIDECORIUM LLC20 May-
ADLARITYDONEPEZIL HYDROCHLORIDECORIUM LLC11 Aug-
AKEEGAABIRATERONE ACETATE; NIRAPARIB TOSYLATEJANSSEN BIOTECH INC27 MarI-980
ALTRENOTRETINOINDOW PHARMACEUTICAL SCIENCES22 Aug-
ALVAIZELTROMBOPAG CHOLINETEVA PHARMACEUTICALS INC05 Nov-
AQVESMEMITAPIVAT SULFATEAGIOS PHARMACEUTICALS INC21 NovODE-522
ARAZLOTAZAROTENEBAUSCH HEALTH US LLC11 May-
ASPRUZYO SPRINKLERANOLAZINESUN PHARMA INDUSTRIES LTD24 Jan-
ATTRUBYACORAMIDIS HYDROCHLORIDEBRIDGEBIO PHARMA INC16 FebODE-506
AUSTEDODEUTETRABENAZINETEVA BRANDED PHARMACEUTICAL PRODUCTS R AND D LLC15 Mar-
AUSTEDODEUTETRABENAZINETEVA BRANDED PHARMACEUTICAL PRODUCTS R AND D LLC15 Sept-
AUSTEDO XRDEUTETRABENAZINETEVA NEUROSCIENCE INC15 Mar-
AUSTEDO XRDEUTETRABENAZINETEVA NEUROSCIENCE INC15 Sept-
AVMAPKI FAKZYNJA CO-PACK (COPACKAGED)AVUTOMETINIB POTASSIUM; DEFACTINIB HYDROCHLORIDEVERASTEM INC29 OctODE-525
BALVERSAERDAFITINIBJANSSEN BIOTECH INC02 FebI-930
BARHEMSYSAMISULPRIDELXO IRELAND DESIGNATED ACTIVITY CO09 Feb-
BREZTRI AEROSPHEREBUDESONIDE; FORMOTEROL FUMARATE; GLYCOPYRROLATEASTRAZENECA AB05 Oct-
BYNFEZIA PENOCTREOTIDE ACETATESUN PHARMACEUTICAL INDUSTRIES LTD15 May-
CABENUVA KITCABOTEGRAVIR; RILPIVIRINEVIIV HEALTHCARE CO18 JulNCE
CERDELGAELIGLUSTAT TARTRATEGENZYME CORP13 Dec-
CLENPIQCITRIC ACID; MAGNESIUM OXIDE; SODIUM PICOSULFATEFERRING PHARMACEUTICALS INC27 Jan-
CONSENSIAMLODIPINE BESYLATE; CELECOXIBPURPLE BIOTECH LTD14 Jun-
COTEMPLA XR-ODTMETHYLPHENIDATENEOS THERAPEUTICS INC25 Jan-
CYSVIEW KITHEXAMINOLEVULINATE HYDROCHLORIDEPHOTOCURE ASA04 Jan-
DAPTOMYCINDAPTOMYCINHIKMA PHARMACEUTICALS USA INC28 Aug-
DSUVIASUFENTANIL CITRATEVERTICAL PHARMACEUTICALS LLC02 Feb-
DYANAVEL XR 10AMPHETAMINE; AMPHETAMINE ASPARTATE/DEXTROAMPHETAMINE SULFATETRIS PHARMA INC24 Sept-
DYANAVEL XR 15AMPHETAMINE; AMPHETAMINE ASPARTATE/DEXTROAMPHETAMINE SULFATETRIS PHARMA INC24 Sept-
DYANAVEL XR 20AMPHETAMINE; AMPHETAMINE ASPARTATE/DEXTROAMPHETAMINE SULFATETRIS PHARMA INC24 Sept-
DYANAVEL XR 5AMPHETAMINE; AMPHETAMINE ASPARTATE/DEXTROAMPHETAMINE SULFATETRIS PHARMA INC24 Sept-
EMPAVELIPEGCETACOPLANAPELLIS PHARMACEUTICALS INC09 AprODE-533
EMPAVELIPEGCETACOPLANAPELLIS PHARMACEUTICALS INC09 DecODE-533
EMPAVELIPEGCETACOPLANAPELLIS PHARMACEUTICALS INC14 DecODE-533
ERLEADAAPALUTAMIDEJANSSEN BIOTECH INC30 Apr-
ERZOFRIPALIPERIDONE PALMITATELUYE INNOMIND PHARMA (SHIJIAZHUANG) CO LTD26 Oct-
EVRYSDIRISDIPLAMGENENTECH INC01 OctODE-400
EVRYSDIRISDIPLAMGENENTECH INC04 OctM-270
FABHALTAIPTACOPAN HYDROCHLORIDENOVARTIS PHARMACEUTICALS CORP30 AugODE-524
FERRIPROXDEFERIPRONECHIESI USA INC25 OctODE-417
FINTEPLAFENFLURAMINE HYDROCHLORIDEUCB INC02 FebPED
FINTEPLAFENFLURAMINE HYDROCHLORIDEUCB INC29 DecPED
GALAFOLDMIGALASTAT HYDROCHLORIDEAMICUS THERAPEUTICS US LLC30 May-
GALAFOLDMIGALASTAT HYDROCHLORIDEAMICUS THERAPEUTICS US LLC17 Aug-
GIMOTIMETOCLOPRAMIDE HYDROCHLORIDEQOL MEDICAL LLC17 Nov-
GOCOVRIAMANTADINE HYDROCHLORIDESUPERNUS PHARMACEUTICALS INC23 Aug-
IHEEZOCHLOROPROCAINE HYDROCHLORIDEHARROW EYE LLC15 Sept-
INGREZZAVALBENAZINE TOSYLATENEUROCRINE BIOSCIENCES INC18 SeptODE-440
INGREZZAVALBENAZINE TOSYLATENEUROCRINE BIOSCIENCES INC14 NovODE-440
INGREZZA SPRINKLEVALBENAZINE TOSYLATENEUROCRINE BIOSCIENCES INC18 SeptI-925
INGREZZA SPRINKLEVALBENAZINE TOSYLATENEUROCRINE BIOSCIENCES INC14 NovI-925
INLEXZOGEMCITABINE HYDROCHLORIDEJANSSEN BIOTECH INC07 NovNP
ITOVEBIINAVOLISIBGENENTECH INC26 AprNCE
ITOVEBIINAVOLISIBGENENTECH INC14 JunNCE
JASCAYDNERANDOMILASTBOEHRINGER INGELHEIM PHARMACEUTICALS INC22 OctODE-546
JESDUVROQDAPRODUSTATGLAXOSMITHKLINE INTELLECTUAL PROPERTY NO 2 LTD ENGLAND13 MarNCE
JULUCADOLUTEGRAVIR SODIUM; RILPIVIRINE HYDROCHLORIDEVIIV HEALTHCARE CO05 Sept-
KLISYRITIRBANIBULINALMIRALL LLC12 MarD-192
KLISYRITIRBANIBULINALMIRALL LLC07 SeptD-192
KOMZIFTIZIFTOMENIBKURA ONCOLOGY INC06 SeptNCE
KORLYMMIFEPRISTONECORCEPT THERAPEUTICS INC22 Aug-
LAZCLUZELAZERTINIB MESYLATEJANSSEN BIOTECH INC18 AprNCE
LENVIMALENVATINIB MESYLATEEISAI INC15 MayPED
LENVIMALENVATINIB MESYLATEEISAI INC15 NovPED
LEVOLETLEVOTHYROXINE SODIUMGENUS LIFE SCIENCES INC23 Mar-
LEVULANAMINOLEVULINIC ACID HYDROCHLORIDESUN PHARMACEUTICAL INDUSTRIES INC12 Jan-
LIQREVSILDENAFIL CITRATECMP DEVELOPMENT LLC24 Dec-
LORBRENALORLATINIBPFIZER INC04 OctODE-349
LUMAKRASSOTORASIBAMGEN INC21 MayODE-507
LUMASONSULFUR HEXAFLUORIDE LIPID-TYPE A MICROSPHERESBRACCO DIAGNOSTICS INC06 Jul-
LUTATHERALUTETIUM LU 177 DOTATATEADVANCED ACCELERATOR APPLICATIONS USA INC25 JulPED
MAVENCLADCLADRIBINEEMD SERONO INC23 Nov-
MIDAZOLAM IN 0.9% SODIUM CHLORIDEMIDAZOLAMINFORLIFE SA20 Jun-
MYFEMBREEESTRADIOL; NORETHINDRONE ACETATE; RELUGOLIXSUMITOMO PHARMA AMERICA INC03 MayM-289
NEFFYEPINEPHRINEARS PHARMACEUTICALS OPERATIONS INC06 Feb-
NOREPINEPHRINE BITARTRATE IN 0.9% SODIUM CHLORIDENOREPINEPHRINE BITARTRATELONG GROVE PHARMACEUTICALS LLC30 Jan-
NUBEQADAROLUTAMIDEBAYER HEALTHCARE PHARMACEUTICALS INC27 FebI-971
NUPLAZIDPIMAVANSERIN TARTRATEACADIA PHARMACEUTICALS INC27 AugPED
NYMALIZENIMODIPINEAZURITY PHARMACEUTICALS INC16 Apr-
OMLONTIOMIDENEPAG ISOPROPYLOCUVEX THERAPEUTICS INC27 DecNCE
OPFOLDAMIGLUSTATAMICUS THERAPEUTICS US LLC16 SeptNP
OPVEENALMEFENE HYDROCHLORIDEINDIVIOR INC10 JulNP
ORIAHNN (COPACKAGED)ELAGOLIX SODIUM,ESTRADIOL,NORETHINDRONE ACETATE; ELAGOLIX SODIUMABBVIE INC20 Aug-
ORILISSAELAGOLIX SODIUMABBVIE INC19 Apr-
ORILISSAELAGOLIX SODIUMABBVIE INC20 Aug-
ORSERDUELACESTRANT HYDROCHLORIDESTEMLINE THERAPEUTICS INC05 JanNCE
OSMOLEX ERAMANTADINE HYDROCHLORIDESUPERNUS PHARMACEUTICALS INC15 Feb-
OTIPRIOCIPROFLOXACINALK-ABELLO INC27 Nov-
OXLUMOLUMASIRAN SODIUMALNYLAM PHARMACEUTICALS INC20 NovODE-415
OZEMPICSEMAGLUTIDENOVO NORDISK INC24 Aug-
OZEMPICSEMAGLUTIDENOVO NORDISK INC10 OctI-961
POSLUMAFLOTUFOLASTAT F-18 GALLIUMBLUE EARTH DIAGNOSTICS LTD23 AugNCE
POSLUMAFLOTUFOLASTAT F-18 GALLIUMBLUE EARTH DIAGNOSTICS LTD22 NovNCE
PREVDUOGLYCOPYRROLATE; NEOSTIGMINE METHYLSULFATEAZURITY PHARMACEUTICALS INC25 Oct-
PYRIDOSTIGMINE BROMIDEPYRIDOSTIGMINE BROMIDEAMNEAL PHARMACEUTICALS LLC18 Jun-
PYRUKYNDMITAPIVAT SULFATEAGIOS PHARMACEUTICALS INC11 OctODE-392
PYRUKYNDMITAPIVAT SULFATEAGIOS PHARMACEUTICALS INC21 NovODE-392
QVAR REDIHALERBECLOMETHASONE DIPROPIONATENORTON WATERFORD LTD26 Jan-
REDEMPLOPLOZASIRAN SODIUMARROWHEAD PHARMACEUTICALS INC10 SeptODE-541
RETEVMOSELPERCATINIBELI LILLY AND CO10 AprPED
RETEVMOSELPERCATINIBELI LILLY AND CO10 OctPED
REZZAYOREZAFUNGIN ACETATEMUNDIPHARMA GMBH11 JulGAIN
REZZAYOREZAFUNGIN ACETATEMUNDIPHARMA GMBH14 JulGAIN
RINVOQUPADACITINIBABBVIE INC09 MarODE-481
RIVFLOZANEDOSIRAN SODIUMNOVO NORDISK INC12 OctODE-531
ROZLYTREKENTRECTINIBGENENTECH INC18 JulODE-448
RYALTRISMOMETASONE FUROATE; OLOPATADINE HYDROCHLORIDEGLENMARK SPECIALTY SA03 SeptNPP
SEPHIENCESEPIAPTERINPTC THERAPEUTICS INC16 AprODE-542
SEPHIENCESEPIAPTERINPTC THERAPEUTICS INC04 SeptODE-542
SINCALIDESINCALIDEMAIA PHARMACEUTICALS INC20 Apr-
SOTALOL HYDROCHLORIDESOTALOL HYDROCHLORIDEALTATHERA PHARMACEUTICALS LLC14 Aug-
SUBLOCADEBUPRENORPHINEINDIVIOR INC22 JunM-314
SUNLENCALENACAPAVIR SODIUMGILEAD SCIENCES INC16 AugNCE
SUNOSISOLRIAMFETOL HYDROCHLORIDEAXSOME MALTA LTD01 JunODE-254
SUNOSISOLRIAMFETOL HYDROCHLORIDEAXSOME MALTA LTD01 NovODE-254
SYFOVREPEGCETACOPLANAPELLIS PHARMACEUTICALS INC14 DecNCE
SYMBRAVOMELOXICAM; RIZATRIPTAN BENZOATEAXSOME THERAPEUTICS INC18 MayNP
SYMTUZACOBICISTAT; DARUNAVIR; EMTRICITABINE; TENOFOVIR ALAFENAMIDE FUMARATEJANSSEN PRODUCTS LP19 Jul-
TADLIQTADALAFILCMP DEVELOPMENT LLC24 Dec-
TAFINLARDABRAFENIB MESYLATENOVARTIS PHARMACEUTICALS CORP29 JunPED
TAFINLARDABRAFENIB MESYLATENOVARTIS PHARMACEUTICALS CORP29 DecPED
TAZVERIKTAZEMETOSTAT HYDROBROMIDEEPIZYME INC03 MayODE-314
THIOLA ECTIOPRONINMISSION PHARMACAL CO14 NovODE*
TRIKAFTA (COPACKAGED)ELEXACAFTOR, IVACAFTOR, TEZACAFTOR; IVACAFTORVERTEX PHARMACEUTICALS INC17 JulODE-543
TRYVIOAPROCITENTANIDORSIA PHARMACEUTICALS LTD26 FebNCE
TRYVIOAPROCITENTANIDORSIA PHARMACEUTICALS LTD02 MarNCE
TRYVIOAPROCITENTANIDORSIA PHARMACEUTICALS LTD26 JulNCE
TUKYSATUCATINIBSEAGEN INC27 AprODE-422
TURALIOPEXIDARTINIB HYDROCHLORIDEDAIICHI SANKYO INC24 JulODE-250
TWYNEOBENZOYL PEROXIDE; TRETINOINMAYNE PHARMA LLC12 Jul-
TYMLOSABALOPARATIDERADIUS HEALTH INC30 Apr-
UTEBZITEBIPENEM PIVOXIL HYDROBROMIDEGLAXOSMITHKLINE LLC06 FebGAIN
VABOMEREMEROPENEM; VABORBACTAMREMPEX PHARMACEUTICALS INC A WHOLLY OWNED SUB OF MELINTA THERAPEUTICS LLC08 JanGAIN
VEKLURYREMDESIVIRGILEAD SCIENCES INC10 JulPED
VEPPANUVEPDEGESTRANTRIGEL PHARMACEUTICALS INC30 JanNCE
VEVYECYCLOSPORINEHARROW EYE LLC20 NovNP
VOYDEYADANICOPANALEXION PHARMACEUTICALS INC02 AugODE-476
VTAMATAPINAROFORGANON LLC13 NovI-956
WEGOVYSEMAGLUTIDENOVO NORDISK INC24 Aug-
WEGOVYSEMAGLUTIDENOVO NORDISK INC10 Oct-
WEGOVY FLEXTOUCHSEMAGLUTIDENOVO NORDISK INC10 OctI-973
WEGOVY HDSEMAGLUTIDENOVO NORDISK INC24 AugNS
WEGOVY HDSEMAGLUTIDENOVO NORDISK INC10 OctNS
WIDAPLIKAMLODIPINE BESYLATE; INDAPAMIDE; TELMISARTANAZURITY PHARMACEUTICALS INC23 JanNP
XDEMVYLOTILANERTARSUS PHARMACEUTICALS INC14 DecNCE
XOFLUZABALOXAVIR MARBOXILGENENTECH INC25 SeptM-187
XOLREMDIMAVORIXAFORX4 PHARMACEUTICALS INC11 DecODE-480
YCANTHCANTHARIDINVERRICA PHARMACEUTICALS INC22 AugNCE
YEZTUGOLENACAPAVIR SODIUMGILEAD SCIENCES INC16 AugNP
ZEJULANIRAPARIB TOSYLATEGLAXOSMITHKLINE LLC27 Mar-
ZEPOSIAOZANIMOD HYDROCHLORIDEBRISTOL MYERS SQUIBB CO30 SeptM-309
ZONISADEZONISAMIDEAZURITY PHARMACEUTICALS INC18 Aug-
Provenance

Source: FDA Orange Book patent and exclusivity files. Rows carrying an exclusivity code have a separate regulatory exclusivity that can outlast the patent shown. Patent expiry alone does not determine when a generic can launch: paediatric extensions, 30-month stays and settlement agreements frequently move the effective date. Delisted patents are excluded.